MerTK: a Membrane Receptor Lost in the Nucleus?
April 21st, 2017 KYRA BORGMAN Single Molecule Biophotonics Group

Classically, membrane receptors are thought to sense signals from outside of the cell, and send these signals via a cascade of different intracellular molecules to the nucleus and finally to the DNA, in order to adapt to environmental changes. We show however for the first time how membrane receptor MerTK itself can travel all the way from the membrane to the nucleus in the context of immune regulation in healthy cells, and interact with the DNA. We use conventional microscopy and biochemical approaches to identify the immunological conditions under which this nuclear translocation takes place and the cellular route that MerTK takes to arrive there, and super-resolution STORM imaging to identify its interaction with the DNA.

PhD Seminar, April 21, 2017, 17:00. ICFO’s Seminar Room