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Photonic antennas provide superresolution nanoimaging of individual receptors on intact cell membranes
Single molecule biophotonics Prof. Dr. María García-Parajo

Activities:

Our research focuses on the development of advanced optical techniques to the study of biological processes at the single molecular level on living cells. We use near-field optical approaches and photonic antennas to provide simultaneous nanoimaging and nanospectroscopy on living cells, in combination with other far-field nanoscopy methods. Fluorescence correlation spectroscopy in ultraconfined volumes, and multi-color single particle tracking are exploited to gain access to dynamic processes down to the µs time resolution. In parallel, our aim is to bring biophysical insights into fundamental biological questions that have important implications for health and disease, including cell biology and immunology, in close collaboration with biologists.


Post-doctoral research position in super-resolution imaging of mechanotransduction in cell adhesion available

Research Topics:
Available Resources:
  • Combined single molecule sensitive confocal/near-field optical microscope (NSOM) fully adapted for biological imaging in physiological conditions.
  • Single-molecule-detection-sensitive scanning confocal microscopy: imaging, polarization, and wavelength sensitive.
  • Dual-color wide-field/TIRF fluorescence microscopy equipped with dual color detection (EM-CCD camera) and environmental chamber for live cell experiments.
  • Multi-parametric single-molecule confocal (Microtime 200) combined with epi-TIRF excitation and dual color detection (EM-CCD camera). Fully adapted for live cell experiments.
  • Lasers: ps-diode-lasers, Ar/Kr+, several HeNe, etc.
  • State-of-art biochemical and cell culture Lab.
Funding:
  • ICREA Institució Catalana de Recerca i Estudis Avançats
  • AGAUR – Agència de Gestió d’Ajuts Universitaris i de Recerca. 2009 SGR 597
  • MICINN– Plan Nacional MAT2011-22887: IMMU-NANO-FORCE
  • http://www.tv3.cat/marato/es/–Development of nanomedicines for enzymatic replacement therapy in Fabry disease.
  • FP7-ICT-2011-7 - NANO-VISTA — Advanced photonic antenna tools for biosensing and cellular nanoimaging (coordinator)

Collaborations:
  • Prof. Carl G. Figdor, Nijmegen Centre for Molecular Life Sciences (NCMLS), Nijmegen (The Netherlands).
  • Dr. Alessandra Cambi, Nijmegen Centre for Molecular Life Sci¬ences (NCMLS), Nijmegen (The Netherlands).
  • Prof. Peter Hinterdorfer, Biophysics Institute, Johannes Kepler University, Linz (Austria).
  • Prof. Vincenzo Cerundolo, Weatherall Institute of Molecular Medicine, University of Oxford (UK).
  • Prof. Jürgen Brugger, École Polytechnique Fédérale de Lausanne (Switzerland).
  • Prof. Hervé Rigneault, Institut Fresnel, Marseille (France).
  • Prof. Niek van Hulst, Institut de Ciències Fotòniques (ICFO), Barcelona (Spain).

Links:
Contact:   maria.garcia-parajo@icfo.es
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