Super resolution imaging

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Description of Activities:

The recent use of super-resolution microscopy in biology is introducing new challenges in the design of projects and in the interpretation of biological data. In the SLN, we implement develop and use two sub diffraction microscopy techniques for biological applications. STED (Stimulated Emission Depletion) microscopy provides resolution in the range of tenths of nanometers for studying cellular details in the molecular scale. STORM (Stochastic Optical Reconstruction Microscopy) imaging uses photo-switchable fluorescent probes to temporally separate the images of individual molecules, allowing the construction of super resolution images with 20nm of typical lateral resolution. The improvements of efficiency, resolution, speed or accuracy are the main axes to open these techniques to address the present and future biological questions.

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