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Spinal Cord Neurons

SLN - Team Loza

Dr. Pablo Loza-Alvarez

    Activities:

We conduct research and development at the cutting-edge of several microscopy and super resolution imaging techniques. We combine different technologies to make them compatible in a multimodal imaging fashion. Research activities include beam engineering, wavefront control and integration of novel light sources with different beam or pulse parameters. We study novel (endogenous and exogenous) contrast agents and new clearing methodologies to be applied to a wide variety of biomedical samples and imaging regimes. We also design novel algorithms for image quantification and analysis. Finally, our research involves optical manipulation tools such as Optical Tweezers and Femtosecond nanosurgery.

The group has well-equipped, modern laboratories for imaging inmicroscopy and super resolution.

    Available Resources:
  • A STED microscope, operating also as a multiphoton (TPEF, SHG).
  • A confocal microscope operating also as a multiphoton (TPEF, SHG, PSHG, THG).
  • A custom made multiphoton microscope system (TPEF, SHG, PSHG, THG).
  • Light Sheet Microscopes (3):
    1. high resolution
    2. high throughput
    3. ultramicroscope
  • A Raman microscope.
  • A custom made Raman microscope.
  • A custom made Adaptive Optics Scanning Laser Ophthalmoscope

Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

SLN - Team Loza

Dr. Pablo Loza-Alvarez

    Former Group Members
  • César Ricardo Alonso, Bio Lab Technician
  • Iván Amat, PhD Student
  • David Artigas, Staff Scientist
  • Remy Ávila, Visiting Scientist
  • Rodrigo Amador Avilés, PhD Student
  • Marymar Becerra, Visiting PhD-student
  • Iain Cormack, Postdoc Researcher
  • Diego Di Battista, Visiting PhD-student
  • Sunil Kumar Girthar, Research Fellow
  • Luz del Carmen Gómez, Visiting Student
  • Raphaël Jorand, Visiting Scientist
  • Leszek Kaczmarek, Visiting Scientist
  • Jacob Licea, Postdoc Researcher
  • Meropi Mari, Visiting Scientist
  • Erwin Martí, Visiting Student
  • Manoj Vathalloor Mathew, PhD Student
  • Emilia Margarita Méndez, Visiting Scientist
  • Jonathan Palero, Postdoc Researcher
  • Omar Palillero, Visiting Scientist
  • Rafael Juliene Ant. Porcar, Research Engineer
  • Sotiris Psilodimitrakopoulos, Research Engineer
  • Mireya Elizabeth Ramírez, Visiting Scientist
  • Israel Rocha-Mendoza, Visiting Scientist
  • Silvia Soria, Postdoc Researcher
  • Elisa Tamariz, Visiting Scientist
  • Anisha Thayil K. Nair, PhD Student
  • César Augusto Valadés, PhD Student

SLN - Team Loza

Dr. Pablo Loza-Alvarez

    Invited Talks
  • FAST-DOT R. Aviles-Espinosa Latin Laser Lab Meeting, Salamanca, Spain, March 5-6, 2012
  • Presentation of STELUM project: Industry-academy teaming up to push the limits of multiphoton microscopy R. Aviles-Espinosa, R. Porcar-Guezenec Bio Light for Health program, ICFO, Barcelona, Spain, May 30-31, 2011
    Talks
  • Ultrashort-pulsed chip-sized lasers for two-photon excited fluorescence imaging R. Aviles-Espinosa, Y. Ding, M. A. Cataluna, D. Nikitichev, E. Rafailov, P. Loza-Alvarez Focus on Microscopy, Singapore, April 1-4, 2012 Paper P1-D13
  • The nonlinear guide-star concept: A fast and noninvasive method to measure and correct sample induced aberrations R. Aviles-Espinosa, J. Andilla, R. Porcar-Guezenec, X. Levecq, D. Artigas, and P. Loza-Alvarez Focus on Microscopy, Singapore, April 1-4, 2012 Paper P1-D13
  • Polarization SHG imaging of nonlinear dyes S. Psilodimitrakopoulos, E. De Meulenaere, J. Vanderleyden, D. Artigas, K. Clays, P. Loza-Alvarez Focus on Microscopy, Konstanz, Germany, April 17-20, 2011
  • Efficient nonlinear excitation of encoded fluorescent proteins in living samples using a semiconductor disk laser R. Aviles-Espinosa, G. Filippidis, C. Hamilton, G. Malcolm, T. Südmeyer, Y. Barbarin, U. Keller, D. Artigas, P. Loza-Alvarez Focus on Microscopy, Konstanz Germany, April 17-20, 2011 Paper 39
  • In vivo third harmonic generation microscopy at 1550nm: Morphogenesis studies in living Caenorhabditis elegans embryos R. Aviles-Espinosa, G. Filippidis, C. Hamilton, G. Malcolm, T. Südmeyer, Y. Barbarin, U. Keller, D. Artigas, P. Loza-Alvarez BioPhotonics and Imaging Conference, (BioPIC 2010), Meath, Ireland, October 18-20, 2010 Paper C8
  • Cell division stage in C. elegans imaged using third harmonic generation microscopy R. Aviles-Espinosa, G. J. Tserevelakis, S. I. C. O. Santos, G. Filippidis, A. J. Krmpot, M. Vlachos, N. Tavernarakis, A. Brodschelm, W. Kaenders, D. Artigas, P. Loza-Alvarez BIOMED, Miami, United States, April 2010
  • Discrimination between collagen and muscle using polarization second harmonic imaging with pixel resolution S. Psilodimitrakopoulos, G. Soria, I. Amat-Roldan, D. Artigas A. M. Planas, P. Loza-Alvarez Focus On Microscopy Conference Series, FOM 2009, Krakow, Poland, April 5-8, 2009
  • Complete optical quality analysis of a non-linear microscope R. Aviles-Espinosa, R. Porcar-Guezenec, D. Zalvidea, D. Artigas, P. Loza-Alvarez Focus on Microscopy Conference Series, FOM 2009, Krakow, Poland, April 5-8, 2009
  • Polarization sensitive second-harmonic generation in nonlinear microcopy S. Psilodimitrakopoulos, I. Amat-Roldan, S. I. C. O. Santos, D. Artigas, P. Loza-Alvarez Hot topics in molecular imaging 2009, TOPIM’09, Les Houches, France, January 26-30, 2009
  • Mean effective orientation of the source molecules in second harmonic imaging microscopy of collagen and muscle S. Psilodimitrakopoulos, I. Amat-Roldan, A. Alfonso García, S. I.C.O. Santos, D. Artigas, P. Loza-Alvarez Scientific Meeting of the Network of Excellence Photonics4life, Brussels, Belgium, November 18-19, 2008
  • Mean effective orientation of the source molecules in second harmonic imaging microscopy of collagen and muscle S. Psilodimitrakopoulos, I. Amat-Roldan, A. Alfonso García, S. I.C.O. Santos, D. Artigas, P. Loza-Alvarez LASERLAB Foresight Workshop and Users Meeting “Trends of Laser Applications in Biology and Biomedicine”, Heraklion, Crete, Greece, October 23-24, 2008
  • Polarization dependant in vivo second harmonic generation imaging of Caenorhabditis elegans vulval, pharynx and body wall muscles S. Psilodimitrakopoulos , S. Santos, I. Amat-Roldan, M. Mathew, A. Thayil K. N, D. Artigas and P. Loza-Alvarez Multiphoton Microscopy in the Biomedical Sciences VIII., Proceedings of the SPIE 6860, 686008-686008-10 (2008)
  • Starch granules as a probe for the polarization at the sample plane of a high resolution multiphoton microscope S. Psilodimitrakopoulos, I. Amat-Roldan, S. Santos, M. Mathew, A. Thayil K. N, D. Zalvidea, D. Artigas and P. Loza-Alvarez Multiphoton Microscopy in the Biomedical Sciences VIII., Proceedings of the SPIE 6860, 68600E- 68600E-11 (2008)
  • In vivo Second Harmonic Generation (SHG) imaging of C. elegans muscles using ultra-short laser pulses S. Psilodimitrakopoulos, S. I. C. O. Santos, I. Amat-Roldan, M. Mathew, A. Thayil K. N, D. Artigas, P. Loza-Alvarez European Worm (C. elegans) meeting - (EWM 2008), Carmona (Seville), Spain, March 29th-April 2nd, 2008
  • Polarization sensitive second harmonic generation imaging for pixel resolution mapping of thick filaments in living C. elegans S. Psilodimitrakopoulos, S. I. C. O. Santos, I. Amat-Roldan, M. Mathew, A. Thayil K. N, D. Artigas, P. Loza-Alvarez European Laboratory for Non-linear Spectroscopy – (LENS), Florence, Italy, 23-26 April, 2008
  • Investigation of ultrashort pulse dispersion through a non-linear microscope I. Amat-Roldán, I. G. Cormack, P. Loza-Alvarez, D. Artigas CLEO/Europe-EQEC, Munich, Germany, June 2005
  • Simple experimental technique for analytically characterizing ultrashort laser pulses I. Amat-Roldán, I. G. Cormack, P. Loza-Alvarez, D. Artigas CLEO/Europe-EQEC, Munich, Germany, June 2005
  • The use of a spectrally resolved interferometric correlation to analytically determine the phase of two unknown ultrashort laser pulses I. Amat-Roldán, I. G. Cormack, P. Loza-Alvarez, D. Artigas CLEO/Europe-EQEC, Munich, Germany, June 2005
  • MEFISTO: measuring the electric field of ultrashort pulses by interferometric spectral trace observation I. Amat-Roldan, I. G. Cormack, P. Loza-Alvarez, D. Artigas CLEO/ IQEC 2005, Baltimore, USA, May 2005
  • Simoultaneous analytical characterisation of two unknown ultrashort laser pulses: blind-MEFISTO I. Amat-Roldan, I. G. Cormack, P. Loza-Alvarez, D. Artigas CLEO/ IQEC 2005, Baltimore, USA, May 2005
  • Two-photon fluorescence spectroscopy by resonant single and double grating waveguide structures S.Soria, A. Thayil, G. Badenes, T. Katchalski, A.A. Friesem, A. Selle, M.A. Bader, G. Marowsky CLEO/QELS 2005, Baltimore, USA, May 2005
  • Two-photon fluorescence spectroscopy based on resonant grating waveguide structures A. Thayil, S.Soria, G. Badenes, T. Katchalski, A.A. Friesem Microtechnologies for new millennium, Sevilla, Spain, May 2005
  • Two-photon fluorescence spectroscopy by resonant grating waveguide structures A. Thayil, S.Soria, G.Badenes, T. Katchalski, A.A. Friesem 2nd Nanospain Workshop, Auditorium Sant Joan de Deu, Barcelona, March 2005
  • Starch solutions based SHG-FROG pulse characterisation in a nonlinear microscope I. Amat-Roldan, I. G. Cormack, P. Loza-Alvarez, D. Artigas CLEO/ IQEC 2004, San Francisco, USA, May 2004
  • Enhanced two-photon fluorescence excitation by resonant waveguide structures S. Soria, T. Katchalski, E. Teitelbaum, A. A. Friesem, G. Marowsky CLEO/ IQEC 2004, San Francisco, USA, May 2004
  • Nonlinear microscopy pulse optimization at the sample plane using second-harmonic generation from starch I. Amat-Roldan, I. G. Cormack, D. Artigas, P. Loza-Alvarez Photonics Europe (SPIE), Strasbourg, France, April 2004
  • Ferroelectric phase transitions and electroclinic effect in thin cells of chiral smectic liquid crystals Y. G. Fokin, T. V. Murzina, O. A. Aktsipetrov, S. Soria, G. Marowsky ECOSS 2003, Prague, Czech Republic, September 2003
  • Ferroelectric ordering and electroclinic effect in thin liquid crystal cells studied by linear and nonlinear optics T. V. Murzina, Y. G. Fokin, O. A. Aktsipetrov, S. Soria, G. Marowsky Optical Science and Technology, SPIE’s 48th Annual Meeting, San Diego, USA, August 2003
    Posters
  • Portable ultrafast semiconductor disc laser for nonlinear bio-imaging applications R. Aviles-Espinosa, C. Hamilton, G. Malcolm, K. J. Weingarten, T. Südmeyer, Y. Barbarin, U. Keller, D. Artigas, P. Loza-Alvarez ICFO Corporate Liaison Program, Barcelona, Spain, November 14, 2011 Paper 02
  • STELUM - Spatio-temporal engineering of Light. Ultimate Multiphoton Microscopy R. Aviles-Espinosa, J. Andilla, R. Porcar-Guezenec, M. Nieto, X. Levecq, D. Artigas, P. Loza-Alvarez Europhotonics Spring School, Casteldefells, Barcelona, March 31, 2012
  • STELUM - Spatio-temporal engineering of Light. Ultimate Multiphoton Microscopy R. Aviles-Espinosa, J. Andilla, R. Porcar-Guezenec, M. Nieto, X. Levecq, D. Artigas, P. Loza-Alvarez Marie Curie Event, Warsaw, Poland, November 18-19, 2011 Paper YH-7
  • Compact ultrafast semiconductor disk laser for nonlinear imaging in living organisms R. Aviles-Espinosa, G. Filippidis, C. Hamilton, G. Malcolm, K. J. Weingarten, T. Südmeyer, Y. Barbarin, U. Keller, D. Artigas, P. Loza-Alvarez, Light for Health, Barcelona, Spain, May 30-31, 2011 Paper 002
  • New technique for aberration measurement and correction in TPEF microscopy R. Aviles-Espinosa, J. Andilla, R. Porcar-Guezenec, O. Olarte, D. Artigas, P. Loza-Alvarez Light for Health, Barcelona, Spain, May 30-31, 2011 Paper 001
  • In vivo recordings of morphogenesis in C. elegans embryos using non-invasive Third Harmonic Generation microscopy R. Aviles-Espinosa, S. I.C.O. Santos, A. Brodschelm, W. G. Kaenders, C. Alonso-Ortega, D. Artigas, P. Loza-Alvarez Photonics 4 Life, Paris, France, November 2010 Paper. P02 (2010).
  • In vivo recordings of morphogenesis in C. elegans embryos using non-invasive Third Harmonic Generation microscopy R. Aviles-Espinosa, S. I.C.O. Santos, A. Brodschelm, W. G. Kaenders, C. Alonso-Ortega, D. Artigas, P. Loza-Alvarez European Molecular Biology Organization (EMBO), Barcelona, Spain, September 4-7, 2010 Paper C-196
  • Optical análisis and aberration correction in a nonlinear microscope R. Aviles-Espinosa, R. Porcar-Guezenec,, D. Artigas, P. Loza-Alvarez, D. Zalvidea OPTOEL, Málaga, Spain, July 2009 Paper STD-5
  • New technique for aberration measurement and correction in TPEF microscopy R. Aviles-Espinosa, J. Andilla, R. Porcar-Guezenec, O. Olarte, D. Artigas, P. Loza-Alvarez Photonics 4 Life, Florence, Italy, 2009
  • Enhanced two-photon fluorescence excitation by resonant waveguide structures S. Soria, T. Katchalski, E. Teitelbaum, A. A. Friesem, G. Marowsky CLEO/ IQEC 2004, San Francisco, USA, May 2004
  • Two photon fluorescence sensor based on resonant grating waveguide structures S. Soria, T. Katchalski, E. Teitelbaum, A. A. Freisem, G. Marowsky Europt(r)ode VII, Madrid, Spain
  • Ferroelectric ordering and electroclinic effect in thin liquid crystal cells studied by linear and nonlinear optics T. V. Murzina, Y. G. Fokin, O. A. Aktsipetrov, S. Soria, G. Marowsky Optical Science and Technology, SPIE’s 48th Annual Meeting, San Diego, USA, August 2003

SLN - Team Loza

Dr. Pablo Loza-Alvarez