Frequency Domain Near Infrared Spectroscopy (FDNIRS) goes beyond the oxygen saturation trend monitoring of current FDA approved continuous wave NIRS systems, making short quantitative measurements possible. FDNIRS not only provides quantitative measures of cerebral oxygenation (SO₂), it also provides quantitative measures of cerebral oxy and deoxyhemoglobin which can be used to determine regional cerebral blood volume (CBV). When combined with the recently developed Diffuse Correlation Spectroscopy (DCS) system, which provide measures of regional cerebral blood flow (CBF), estimates of regional cerebral metabolic rate of oxygen consumption (CMRO₂),) can be obtained. Thus FDNIRS/DCS provide bedside measures of SO₂),, CBV, CBF and CMRO₂),. Our team has characterized changes in these cerebral measures with normal development and demonstrated the potential of these measures to detect perinatal brain injury and monitor response to therapeutic hypothermia. Currently we are also exploring the potential of these systems in the management of neonatal hydrocephalus and in the intraoperative and peri-operative management of neonatal congenital heart disease. Common emerging themes of our research are 1) SO₂), alone is a relatively insensitive and nonspecific measure of brain health, and 2) independent measures of CBV and CBF are essential to better understand cerebral physiology in diseased states.


Wednesday, July 15, 2015, 12:00. Seminar Room

Hosted by Prof. Turgut Durduran