Optical detection techniques play a major role in basic research and applied bio-medical research. Semiconductor-based bio-sensors can take advantage of mature semiconductor fabrication techniques that allow uniquely tailored solutions for optical bio-imaging. Semiconductor-based miniature bio-sensors will enable new solutions for bio-medical diagnostics, in vivo imaging, and spectroscopy that are low cost, highly parallel, and portable.

In this presentation, I will review our research of miniature integrated semiconductor biosensors. System design, sensor fabrication and optimization of semiconductor integrated optical bio-sensors for fluorescence, reflection, and index of refraction sensing will be reviewed. I will discuss our progress on integrating these sensors with photonic crystal nano-structures for index-of-refraction-based bio-diagnostics, and on optimizing sensor designs for detection of small scattering changes due to hemodynamic changes in the brain. Applications of these integrated sensors include bio-medical diagnostics in microflow channels, in vivo continuous monitoring of tumors, and in vivo imaging of neural activity using minimally invasive sensor arrays.

Seminar, 3rd of November, 9:30h. Conference Room