All day
Place: ICFO Auditorium
Patricia Bassereau (Institut Curie)
"Shaping lipid membranes with proteins"
Abstract:
Cell membranes are highly deformable surfaces and have to be strongly curved to a few tens of nanometers, for instance during exchanges when small buds or tubules form and eventually detach from cell membranes. These membrane-shaping processes always require to interact with proteins - for instance, proteins with an intrinsically-curved shape. In vitro experiments combined to theoretical models have been instrumental for understanding how proteins shape cellular membranes by bending or scissioning them, and conversely how membrane curvature is a cue for the local enrichment of proteins or affect their activity. In this lecture, I will discuss examples of proteins with intrinsically-curved shapes (BAR-domain proteins) or not (Caveolin complex) that are enriched in curved membranes, and how curvature affects the activity of an ABC transporter.
Bio:
Patricia Bassereau is CNRS Research Director at the Institut Curie (Paris) and leads the group "Membranes and cellular functions". She obtained a PhD in Soft Matter in Montpellier where she started her carrier on the structure of self-assembled surfactant-based systems. After a year at IBM Almaden Center (San Jose, USA), she moved to Institut Curie in 1993 to work on "Physics of the Cell" and cell membranes. For her research, she develops a multidisciplinary approach, largely based on synthetic biology and biomimetic systems, as well as quantitative mechanical and microscopy methods to understand the dynamics, the organization and the mechanics of biological membranes.
In 2015 she received the Suffrage Science Award (Royal Society, UK), in 2017 the Emmy Noether Distinction for Women in Physics (EPS), the Avanti Award in Lipids of the Biophysical Society (BPS) in 2022; she is Fellow of the BPS since 2018 and Elected EMBO Member since 2020.
All day
Place: ICFO Auditorium
Patricia Bassereau (Institut Curie)
"Shaping lipid membranes with proteins"
Abstract:
Cell membranes are highly deformable surfaces and have to be strongly curved to a few tens of nanometers, for instance during exchanges when small buds or tubules form and eventually detach from cell membranes. These membrane-shaping processes always require to interact with proteins - for instance, proteins with an intrinsically-curved shape. In vitro experiments combined to theoretical models have been instrumental for understanding how proteins shape cellular membranes by bending or scissioning them, and conversely how membrane curvature is a cue for the local enrichment of proteins or affect their activity. In this lecture, I will discuss examples of proteins with intrinsically-curved shapes (BAR-domain proteins) or not (Caveolin complex) that are enriched in curved membranes, and how curvature affects the activity of an ABC transporter.
Bio:
Patricia Bassereau is CNRS Research Director at the Institut Curie (Paris) and leads the group "Membranes and cellular functions". She obtained a PhD in Soft Matter in Montpellier where she started her carrier on the structure of self-assembled surfactant-based systems. After a year at IBM Almaden Center (San Jose, USA), she moved to Institut Curie in 1993 to work on "Physics of the Cell" and cell membranes. For her research, she develops a multidisciplinary approach, largely based on synthetic biology and biomimetic systems, as well as quantitative mechanical and microscopy methods to understand the dynamics, the organization and the mechanics of biological membranes.
In 2015 she received the Suffrage Science Award (Royal Society, UK), in 2017 the Emmy Noether Distinction for Women in Physics (EPS), the Avanti Award in Lipids of the Biophysical Society (BPS) in 2022; she is Fellow of the BPS since 2018 and Elected EMBO Member since 2020.