Hour: From 12:00h to 13:00h
Place: Seminar Room
INSIGHT SEMINAR: 3D architecture and mechanism of touch detection in the Pacinian corpuscle
Pacinian corpuscles are specialized mechanoreceptors that detect high-frequency vibration in the skin of many vertebrates, enabling texture discrimination and precise tactile tasks. Corpuscles comprise a multilayered outer core surrounding an inner core, which contains lamellar Schwann cells and a neuronal afferent terminal. The spatial organization and functional roles of these components remain poorly understood. Using Focused Ion Beam Scanning Electron Microscopy (FIB-SEM), we determined the high-resolution 3D architecture of an entire Pacinian corpuscle and utilized in situ electrophysiology to reveal the contributions of its cellular component to touch detection. We show that, contrary to the prevailing model, the outer core plays a minimal role in the sensory tuning of corpuscles to high-frequency vibration. Instead, this tuning arises from the inner core, where the afferent terminal acts as the primary touch sensor, detecting vibrations due to its sensitivity to stimulus velocity. Mechanosensitive lamellar Schwann cells also detect touch and enhance the afferent’s sensitivity to mechanical stimuli. We present a new model, in which the functional tuning of Pacinian corpuscles to vibration is enabled by an interplay between mechanosensitive lamellar Schwann cells and the afferent terminal in the inner core.
Hour: From 12:00h to 13:00h
Place: Seminar Room
INSIGHT SEMINAR: 3D architecture and mechanism of touch detection in the Pacinian corpuscle
Pacinian corpuscles are specialized mechanoreceptors that detect high-frequency vibration in the skin of many vertebrates, enabling texture discrimination and precise tactile tasks. Corpuscles comprise a multilayered outer core surrounding an inner core, which contains lamellar Schwann cells and a neuronal afferent terminal. The spatial organization and functional roles of these components remain poorly understood. Using Focused Ion Beam Scanning Electron Microscopy (FIB-SEM), we determined the high-resolution 3D architecture of an entire Pacinian corpuscle and utilized in situ electrophysiology to reveal the contributions of its cellular component to touch detection. We show that, contrary to the prevailing model, the outer core plays a minimal role in the sensory tuning of corpuscles to high-frequency vibration. Instead, this tuning arises from the inner core, where the afferent terminal acts as the primary touch sensor, detecting vibrations due to its sensitivity to stimulus velocity. Mechanosensitive lamellar Schwann cells also detect touch and enhance the afferent’s sensitivity to mechanical stimuli. We present a new model, in which the functional tuning of Pacinian corpuscles to vibration is enabled by an interplay between mechanosensitive lamellar Schwann cells and the afferent terminal in the inner core.
All Insight Seminars
Hour: From 12:00h to 13:00h
Place: Elements Room
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Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Seminar Room
Hour: From 12:00h to 13:00h
Place: Seminar Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 16:00h to 17:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room and Online (Teams)
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 11:00h to 12:00h
Place: Seminar Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room
Hour: From 12:00h to 13:00h
Place: Elements Room