A high goal of clinical medicine is molecular imaging— measuring simultaneously spatially and chemically resolved maps of the body to probe metabolic function/disfunction — in a way that is scalable, rapid and minimally invasive to patients. For a decade or so this has been feasible via magnetic resonance imaging (MRI), given the initial condition of ex-vivo substrates with near-unity 13C spin polarization, and in the past 5 years, my lab at IBEC has been the first to translate these methods to tissue-on-a-chip systems, which are aiming at high throughput, realistic models of glycolysis, the pentose-phosphate pathway, and cellular redox states compared to in vitro. In this talk I will explain how these techniques are performed, from the quantum mechanics to the bioengieering, and demonstrate their results.