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Light Seminars
July 12, 2016
L4H Seminar REGINE CHOE 'Can Diffuse Optical and Correlation Tomography Predict Treatment Efficacy for Bone Injury and Cancer?'

L4H Seminar REGINE CHOE 'Can Diffuse Optical and Correlation Tomography Predict Treatment Efficacy for Bone Injury and Cancer?'

REGINE CHOE University of Rochester Medical Center
Tuesday, July 12, 2016, 12:00. Seminar Room
REGINE CHOE
University of Rochester Medical Center
Diffuse optical and correlation tomography have a great potential to monitor and predict the efficacy of treatments that affect vascular parameters, since they provide non-invasive measurements of oxygenated and deoxygenated hemoglobin, and blood flow. In addition, the use of non-ionizing radiation and technologically simple, fast, inexpensive instrumentation makes diffuse optics attractive for translational research.

In this presentation, clinical and preclinical research tools and approaches to test the capabilities of diffuse optics in early prediction of therapeutic efficacy will be introduced. For bone graft monitoring, temporal and spatial blood flow distributions from murine segmental defect model will be presented for different graft types with varying healing capacity: autografts, allografts, and allografts with tissue-engineered periosteum. For breast cancer monitoring, high correlation between temporal blood flow changes and the treatment efficacy assessed by tumor size changes in a murine breast cancer model will be shown. In addition, the potential of a multi-parametric approach based on clinical diffuse optical measurements to predict neoadjuvant chemotherapy efficacy will be demonstrated.

Diffuse optical and correlation tomography have a great potential to monitor and predict the efficacy of treatments that affect vascular parameters, since they provide non-invasive measurements of oxygenated and deoxygenated hemoglobin, and blood flow. In addition, the use of non-ionizing radiation and technologically simple, fast, inexpensive instrumentation makes diffuse optics attractive for translational research.

In this presentation, clinical and preclinical research tools and approaches to test the capabilities of diffuse optics in early prediction of therapeutic efficacy will be introduced. For bone graft monitoring, temporal and spatial blood flow distributions from murine segmental defect model will be presented for different graft types with varying healing capacity: autografts, allografts, and allografts with tissue-engineered periosteum. For breast cancer monitoring, high correlation between temporal blood flow changes and the treatment efficacy assessed by tumor size changes in a murine breast cancer model will be shown. In addition, the potential of a multi-parametric approach based on clinical diffuse optical measurements to predict neoadjuvant chemotherapy efficacy will be demonstrated.


Tuesday, July 12, 2016, 12:00. Seminar Room

Hosted by Prof. Turgut Durduran
Light Seminars
July 12, 2016
L4H Seminar REGINE CHOE 'Can Diffuse Optical and Correlation Tomography Predict Treatment Efficacy for Bone Injury and Cancer?'

L4H Seminar REGINE CHOE 'Can Diffuse Optical and Correlation Tomography Predict Treatment Efficacy for Bone Injury and Cancer?'

REGINE CHOE University of Rochester Medical Center
Tuesday, July 12, 2016, 12:00. Seminar Room
REGINE CHOE
University of Rochester Medical Center
Diffuse optical and correlation tomography have a great potential to monitor and predict the efficacy of treatments that affect vascular parameters, since they provide non-invasive measurements of oxygenated and deoxygenated hemoglobin, and blood flow. In addition, the use of non-ionizing radiation and technologically simple, fast, inexpensive instrumentation makes diffuse optics attractive for translational research.

In this presentation, clinical and preclinical research tools and approaches to test the capabilities of diffuse optics in early prediction of therapeutic efficacy will be introduced. For bone graft monitoring, temporal and spatial blood flow distributions from murine segmental defect model will be presented for different graft types with varying healing capacity: autografts, allografts, and allografts with tissue-engineered periosteum. For breast cancer monitoring, high correlation between temporal blood flow changes and the treatment efficacy assessed by tumor size changes in a murine breast cancer model will be shown. In addition, the potential of a multi-parametric approach based on clinical diffuse optical measurements to predict neoadjuvant chemotherapy efficacy will be demonstrated.

Diffuse optical and correlation tomography have a great potential to monitor and predict the efficacy of treatments that affect vascular parameters, since they provide non-invasive measurements of oxygenated and deoxygenated hemoglobin, and blood flow. In addition, the use of non-ionizing radiation and technologically simple, fast, inexpensive instrumentation makes diffuse optics attractive for translational research.

In this presentation, clinical and preclinical research tools and approaches to test the capabilities of diffuse optics in early prediction of therapeutic efficacy will be introduced. For bone graft monitoring, temporal and spatial blood flow distributions from murine segmental defect model will be presented for different graft types with varying healing capacity: autografts, allografts, and allografts with tissue-engineered periosteum. For breast cancer monitoring, high correlation between temporal blood flow changes and the treatment efficacy assessed by tumor size changes in a murine breast cancer model will be shown. In addition, the potential of a multi-parametric approach based on clinical diffuse optical measurements to predict neoadjuvant chemotherapy efficacy will be demonstrated.


Tuesday, July 12, 2016, 12:00. Seminar Room

Hosted by Prof. Turgut Durduran

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